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In one review of the drug dating back to 1970 published in Archives of Disease in Childhood, doctors reported that children who were given metoclopramide for minor stomach ailments manifested “alarming side-reactions during treatment.
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Although the label for metoclopramide does not include the indications of nausea and vomiting during pregnancy, metoclopramide is the antiemetic drug of choice in some European countries and in Israel.
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Pyridoxine (vitamin B 6), with or without doxylamine, has been recommended for treating nausea and vomiting in pregnancy.
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The time it takes for the pill to be expelled from the stomach into the duodenum is measured by monitoring the time point at which the acid readings of the stomach are replaced by the dramatic increase in pH as the capsule enters the duodenum.
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There is now good evidence to suggest that 5 HT 3 antagonists and dexamethasone are the most effective antiemetics in the prophylaxis of pediatric POV.
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